Rintaro Hashizume Selected Research

Brain Stem Neoplasms (Brain Stem Tumor)

11/2020	Convection-Enhanced Delivery of Enhancer of Zeste Homolog-2 (EZH2) Inhibitor for the Treatment of Diffuse Intrinsic Pontine Glioma.
2/2018	New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model.
4/2017	Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas.
1/2017	Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.
5/2012	An experimental xenograft mouse model of diffuse pontine glioma designed for therapeutic testing.
1/2010	A human brainstem glioma xenograft model enabled for bioluminescence imaging.

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Rintaro Hashizume Research Topics

Disease

44	Neoplasms (Cancer) 01/2022 - 04/2008
21	Glioma (Gliomas) 01/2022 - 01/2010
19	Brain Neoplasms (Brain Tumor) 01/2021 - 04/2008
14	Diffuse Intrinsic Pontine Glioma 01/2021 - 01/2015
7	Glioblastoma (Glioblastoma Multiforme) 01/2019 - 01/2010
6	Brain Stem Neoplasms (Brain Stem Tumor) 11/2020 - 01/2010
5	Medulloblastoma 01/2019 - 08/2012
2	Carcinogenesis 01/2022 - 04/2017
2	Meningioma (Meningiomas) 01/2021 - 01/2019
2	Astrocytoma (Pilocytic Astrocytoma) 05/2012 - 12/2011
1	Ependymoma 01/2019
1	Polyploidy 12/2017
1	Rhabdoid Tumor (Rhabdoid Tumors) 12/2017
1	Obesity 10/2017
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2017
1	Typical Teratoid Rhabdoid Tumor 11/2016
1	Neoplasm Metastasis (Metastasis) 09/2015
1	Sarcoma (Soft Tissue Sarcoma) 05/2012

Drug/Important Bio-Agent (IBA)

17	dipinacoline glutamateIBA 01/2021 - 05/2012
13	Histones (Histone)IBA 10/2020 - 05/2013
5	Pharmaceutical PreparationsIBA 01/2020 - 05/2012
4	Lysine (L-Lysine)FDA Link 10/2020 - 04/2017
4	Biological ProductsIBA 01/2019 - 12/2012
4	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 01/2010
4	LuciferasesIBA 01/2016 - 01/2010
3	Proteins (Proteins, Gene)FDA Link 10/2020 - 04/2017
3	ChromatinIBA 10/2020 - 01/2016
3	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2019 - 11/2016
3	Phosphotransferases (Kinase)IBA 01/2019 - 05/2012
3	DNA (Deoxyribonucleic Acid)IBA 12/2017 - 01/2010
3	PLX 4720IBA 11/2016 - 12/2011
3	Telomerase (Telomerase Reverse Transcriptase)IBA 12/2012 - 04/2008
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2017
2	tazemetostatIBA 01/2022 - 11/2020
2	palbociclibIBA 01/2021 - 11/2016
2	Antineoplastic Agents (Antineoplastics)IBA 01/2019 - 04/2008
2	MethyltransferasesIBA 01/2018 - 10/2017
2	Polycomb Repressive Complex 2IBA 01/2018 - 04/2017
2	CytokinesIBA 01/2016 - 12/2014
2	Ion Channels (Ion Channel)IBA 09/2015 - 08/2012
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/2012 - 04/2010
2	OligonucleotidesIBA 04/2010 - 04/2008
1	platelet-derived growth factor AIBA 01/2022
1	NestinIBA 01/2022
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2021
1	SurvivinIBA 01/2021
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2021
1	Polycomb Repressive Complex 1IBA 10/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	Dasatinib (BMS 354825)FDA Link 01/2020
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2020
1	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2019
1	histone H3 trimethyl Lys4IBA 01/2019
1	1- (6- (3,5- dichloro- 4- hydroxyphenyl)- 4- ((4- ((dimethylamino)methyl)cyclohexyl)amino)- 1,5- naphthyridin- 3- yl)ethanoneIBA 11/2018
1	Irinotecan (Camptosar)FDA LinkGeneric 02/2018
1	Deubiquitinating EnzymesIBA 01/2018
1	Carbon-13IBA 01/2018
1	Circulating Tumor DNAIBA 01/2018
1	Pyruvic Acid (Pyruvate)IBA 01/2018
1	CarbonIBA 01/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2018
1	ubiquinone 7IBA 10/2017
1	Adiponectin ReceptorsIBA 10/2017
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2017
1	Methionine (L-Methionine)FDA Link 04/2017
1	Nucleosomes (Nucleosome)IBA 04/2017
1	Cyclin-Dependent Kinase 4IBA 11/2016
1	MTOR InhibitorsIBA 11/2016
1	Everolimus FDA Link 11/2016
1	AZD 6244IBA 11/2016
1	Retinoblastoma ProteinIBA 11/2016
1	GalactosidasesIBA 02/2016
1	Annexin A5IBA 02/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2016
1	resiquimodIBA 01/2016
1	TOR Serine-Threonine KinasesIBA 01/2016
1	Imiquimod (Aldara)FDA LinkGeneric 01/2016
1	Antipsychotic Agents (Antipsychotics)IBA 09/2015
1	Potassium Channels (Potassium Channel)IBA 09/2015
1	Thioridazine (Mellaril)FDA LinkGeneric 09/2015
1	adavosertibIBA 03/2014
1	vasectrin I (VS I)IBA 03/2014
1	LigandsIBA 12/2013
1	MicroRNAs (MicroRNA)IBA 01/2013
1	RibonucleoproteinsIBA 12/2012
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 08/2012
1	p38 Mitogen-Activated Protein KinasesIBA 08/2012
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 05/2012
1	Cyclin-Dependent Kinase Inhibitor p16IBA 05/2012

Therapy/Procedure

26	Therapeutics 01/2021 - 04/2008
5	Radiotherapy 01/2021 - 11/2016
3	Drug Therapy (Chemotherapy) 01/2021 - 01/2010
1	Oncolytic Virotherapy 01/2021
1	Precision Medicine 01/2019
1	Investigational Therapies (Experimental Therapy) 01/2017
1	Immunotherapy 12/2014
1	Quantum Dots (Quantum Dot) 12/2013